Regulation of hepatic gluconeogenesis by nuclear factor Y transcription factor in mice
نویسندگان
چکیده
منابع مشابه
Regulation of hepatic fasting response by PPAR coactivator-1 (PGC-1): Requirement for hepatocyte nuclear factor 4 in gluconeogenesis
The liver plays several critical roles in the metabolic adaptation to fasting. We have shown previously that the transcriptional coactivator peroxisome proliferator-activated receptor coactivator-1 (PGC-1 ) is induced in fasted or diabetic liver and activates the entire program of gluconeogenesis. PGC-1 interacts with several nuclear receptors known to bind gluconeogenic promoters including the...
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Nuclear factor Y (NF-Y) is an evolutionarily conserved trimeric transcription factor complex present in nearly all eukaryotes. The heterotrimeric NF-Y complex consists of three subunits, NF-YA, NF-YB, and NF-YC, and binds to the CCAAT box in the promoter regions of its target genes to regulate their expression. Yeast and mammal genomes generally have single genes with multiple splicing isoforms...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2018
ISSN: 0021-9258
DOI: 10.1074/jbc.ra117.000508